Association between air pollution and primary liver cancer in European and east Asian populations: a Mendelian randomization study.

ABSTRACT:

Purpose

The incidence of primary liver cancer is increasing year by year, with environmental factors playing a non-negligible role. At present, many studies are still disputing whether air pollution is associated with primary liver cancer incidence, and it is difficult to draw causal inferences. Therefore, in this study, we used two-sample Mendelian randomization (MR) to assess the causal relationship between air pollution (including PM2.5, PM2.5-10, PM10, nitrogen dioxide and nitrogen oxides) and primary liver cancer risk and its related biomarkers (Alpha-fetoprotein, Osteopontin, Glypican-3 and Arginase-1).

Patients and methods

We used large-scale publicly available genome-wide association studies (GWAS) summary data to conduct MR analyses of European and East Asian popula

SUBMITTER: Sun M 

PROVIDER: S-EPMC10415013 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature