Circ_0008285 Regulates Glioma Progression via the miR-384/HMGB1 Axis.

ABSTRACT:

Background

Recent studies indicate that circular RNAs (circRNAs) have been implicated in the initiation or progression of a wide spectrum of diseases. In the current study, we explored the potential engagement of circ_0008285 in glioma and investigated the downstream regulators.

Methods

The detection of circ_0008285 level in glioma specimens and cell lines was conducted by quantitative real-time polymerase chain reaction. The chi-squared test was employed to evaluate the relationship between the circ_0008285 level and the clinical features of glioma patients. The roles of circ_0008285 on the proliferation and apoptosis of glioma cells were studied by knockdown experiment. Meanwhile, the regulatory relationship of circ_0008285, miR-384, and high mobility group protein B1 (HMG

SUBMITTER: Yan M 

PROVIDER: S-EPMC10415084 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature