Generalised interrelations among mutation rates drive the genomic compliance of Chargaff's second parity rule.

ABSTRACT: Chargaff's second parity rule (PR-2), where the complementary base and k-mer contents are matching within the same strand of a double stranded DNA (dsDNA), is a phenomenon that invited many explanations. The strict compliance of nearly all nuclear dsDNA to PR-2 implies that the explanation should also be similarly adamant. In this work, we revisited the possibility of mutation rates driving PR-2 compliance. Starting from the assumption-free approach, we constructed kinetic equations for unconstrained simulations. The results were analysed for their PR-2 compliance by employing symbolic regression and machine learning techniques. We arrived to a generalised set of mutation rate interrelations in place in most species that allow for their full PR-2 compliance. Importantly, our constraints ex

SUBMITTER: Pflughaupt P 

PROVIDER: S-EPMC10415130 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature