Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study.

ABSTRACT:

Background and objective

Uterine leiomyoma is the most common benign tumor in females of reproductive age. However, its causes have never been fully understood. The objective of our study was to analyze the causal association between various factors and uterine leiomyoma using Mendelian randomization (MR).

Methods

Genetic variables associated with risk factors were obtained from genome-wide association studies. Summary-level statistical data for uterine leiomyoma were obtained from FinnGen and the UK Biobank (UKB) consortium. We used inverse variance weighted, MR-Egger, and weighted median methods in univariate analysis. Multivariable MR analysis was used to identify independent risk factors. A fixed-effect model meta-analysis was used to combine the results of the FinnGen a

SUBMITTER: Qu Y 

PROVIDER: S-EPMC10415162 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature