AlphaPeptStats: an open-source Python package for automated and scalable statistical analysis of mass spectrometry-based proteomics.

ABSTRACT:

Summary

The widespread application of mass spectrometry (MS)-based proteomics in biomedical research increasingly requires robust, transparent, and streamlined solutions to extract statistically reliable insights. We have designed and implemented AlphaPeptStats, an inclusive Python package with currently with broad functionalities for normalization, imputation, visualization, and statistical analysis of label-free proteomics data. It modularly builds on the established stack of Python scientific libraries and is accompanied by a rigorous testing framework with 98% test coverage. It imports the output of a range of popular search engines. Data can be filtered and normalized according to user specifications. At its heart, AlphaPeptStats provides a wide range of robust statistical alg

SUBMITTER: Krismer E 

PROVIDER: S-EPMC10415174 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature