Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape.

ABSTRACT: The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited. Here, we map the transcriptome and epigenome landscape as well as chromatin interactions of human trophoblast stem cells and their transition into extravillous trophoblast cells. We show that integrating chromatin accessibility, long-range chromatin interactions, transcriptomic, and transcription factor binding motif enrichment enables identification of transcription factors and regulatory mechanisms critical for extravillous trophoblast cell development. We elucidate functional roles for TFAP2C, SNAI1, and EPAS1 in the regulation of extravillous trophoblast cell development. EPAS1 is ident

SUBMITTER: Varberg KM 

PROVIDER: S-EPMC10415281 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature