Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche.

ABSTRACT: While cell division is essential for self-renewal and differentiation of stem cells and progenitors, dormancy is required to maintain the structure and function of the stem-cell niche. Here we use the hair follicle to show that during growth, the mesenchymal niche of the hair follicle, the dermal papilla (DP), is maintained quiescent by the activity of Hdac1 and Hdac2 in the DP that suppresses the expression of cell-cycle genes. Furthermore, Hdac1 and Hdac2 in the DP promote the survival of DP cells throughout the hair cycle. While during growth and regression this includes downregulation of p53 activity and the control of p53-independent programs, during quiescence, this predominantly involves p53-independent mechanisms. Remarkably, Hdac1 and Hdac2 in the DP during the growth phase also p

SUBMITTER: Sibony-Benyamini H 

PROVIDER: S-EPMC10415406 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature