PET/MRI of hypoxia and vascular function in ER-positive breast cancer: correlations with immunohistochemistry.

ABSTRACT:

Objectives

To explore the relationship between indices of hypoxia and vascular function from ¹⁸F-fluoromisonidazole ([¹⁸F]-FMISO)-PET/MRI with immunohistochemical markers of hypoxia and vascularity in oestrogen receptor-positive (ER +) breast cancer.

Methods

Women aged  > 18 years with biopsy-confirmed, treatment-naïve primary ER + breast cancer underwent [¹⁸F]-FMISO-PET/MRI prior to surgery. Parameters of vascular function were derived from DCE-MRI using the extended Tofts model, whilst hypoxia was assessed using the [¹⁸F]-FMISO influx rate constant, K_i. Histological tumour sections were stained with CD31, hypoxia-inducible factor (HIF)-1α, and carbonic anhydrase IX (CAIX). The number of tumour microvessels, median vess

SUBMITTER: Carmona-Bozo JC 

PROVIDER: S-EPMC10415421 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature