Quantitative background parenchymal enhancement and fibro-glandular density at breast MRI: Association with BRCA status.

ABSTRACT:

Objectives

To investigate whether MRI-based measurements of fibro-glandular tissue volume, breast density (MRBD), and background parenchymal enhancement (BPE) could be used to stratify two cohorts of healthy women: BRCA carriers and women at population risk of breast cancer.

Methods

Pre-menopausal women aged 40-50 years old were scanned at 3 T, employing a standard breast protocol including a DCE-MRI (35 and 30 participants in high- and low-risk groups, respectively). The dynamic range of the DCE protocol was characterised and both breasts were masked and segmented with minimal user input to produce measurements of fibro-glandular tissue volume, MRBD, and voxelwise BPE. Statistical tests were performed to determine inter- and intra-user repeatability, evaluate the symmetry b

SUBMITTER: Goodburn R 

PROVIDER: S-EPMC10415521 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature