Identification of TGF-β-related genes in cardiac hypertrophy and heart failure based on single cell RNA sequencing.

ABSTRACT:

Background

Heart failure (HF) remains a huge medical burden worldwide. Pathological cardiac hypertrophy is one of the most significant phenotypes of HF. Several studies have reported that the TGF-β pathway plays a double-sided role in HF. Therefore, TGF-β-related genes (TRGs) may be potential therapeutic targets for cardiac hypertrophy and HF. However, the roles of TRGs in HF at the single-cell level remain unclear.

Method

In this study, to analyze the expression pattern of TRGs during the progress of cardiac hypertrophy and HF, we used three public single-cell RNA sequencing datasets for HF (GSE161470, GSE145154, and GSE161153), one HF transcriptome data (GSE57338), and one hypertrophic cardiomyopathy transcriptome data (GSE141910). Weighted gene co-expression network analy

SUBMITTER: Huang K 

PROVIDER: S-EPMC10415570 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature