Nasopharyngeal fungal subtypes of infant bronchiolitis and disease severity risk.

ABSTRACT:

Background

Bronchiolitis is a leading cause of infant hospitalization. Recent research suggests the heterogeneity within bronchiolitis and the relationship of airway viruses and bacteria with bronchiolitis severity. However, little is known about the pathobiological role of fungi. We aimed to identify bronchiolitis mycotypes by integrating fungus and virus data, and determine their association with bronchiolitis severity and biological characteristics.

Methods

In a multicentre prospective cohort study of 398 infants (age <1 year, male 59%) hospitalized for bronchiolitis, we applied clustering approaches to identify mycotypes by integrating nasopharyngeal fungus (detected in RNA-sequencing data) and virus data (respiratory syncytial virus [RSV], rhinovirus [RV]) at hospitaliz

SUBMITTER: Shibata R 

PROVIDER: S-EPMC10415709 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature