Are steroid hormones and autistic traits affected by metformin? First insights from a pilot.

ABSTRACT:

Background

Different lines of evidence imply that metformin could alter steroid hormone homeostasis and thereby improve social impairment. Here, we tried to correlate the impact of metformin treatment on alterations in steroid hormones and autism spectrum traits before versus after treatment with metformin.

Material & methods

Urine steroid hormones were measured using gas chromatography mass spectrometry in 12 male subjects (54.2 ± 9.1 years, 177.3 ± 4.1 cm, 80 ± 10.4 kg) and 7 female subjects (64.14 ± 18.0 years, 162.7 ± 4.1 cm, 76.1 ± 10.4 kg). Furthermore, a questionnaire on autism spectrum traits (Autism Spectrum Questionnaire]) was administered prior to and after metformin treatment.

Results

Overall, a decrease of steroid hormones were detected, which were most p

SUBMITTER: Gasser B 

PROVIDER: S-EPMC10415721 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature