Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss.

ABSTRACT: Delirium is a severe acute neuropsychiatric syndrome that commonly occurs in the elderly and is considered an independent risk factor for later dementia. However, given its inherent complexity, few animal models of delirium have been established and the mechanism underlying the onset of delirium remains elusive. Here, we conducted a comparison of three mouse models of delirium induced by clinically relevant risk factors, including anesthesia with surgery (AS), systemic inflammation, and neurotransmission modulation. We found that both bacterial lipopolysaccharide (LPS) and cholinergic receptor antagonist scopolamine (Scop) induction reduced neuronal activities in the delirium-related brain network, with the latter presenting a similar pattern of reduction as found in delirium patients. Con

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10415773 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature