Spatial patterns of gray and white matter compromise relate to age of seizure onset in temporal lobe epilepsy.

ABSTRACT:

Objective

Temporal Lobe Epilepsy (TLE) is frequently a neurodevelopmental disorder, involving subcortical volume loss, cortical atrophy, and white matter (WM) disruption. However, few studies have addressed how these pathological changes in TLE relate to one another. In this study, we investigate spatial patterns of gray and white matter degeneration in TLE and evaluate the hypothesis that the relationship among these patterns varies as a function of the age at which seizures begin.

Methods

Eighty-two patients with TLE and 59 healthy controls were enrolled. T1-weighted images were used to obtain hippocampal volumes and cortical thickness estimates. Diffusion-weighted imaging was used to obtain fractional anisotropy (FA) and mean diffusivity (MD) of the superficial WM (SWM) a

SUBMITTER: Ballerini A 

PROVIDER: S-EPMC10415805 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature