Cuproptosis-related genes prediction feature and immune microenvironment in major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a severe, unpredictable, ill-cured, relapsing neuropsychiatric disorder. A recently identified type of death called cuproptosis has been linked to a number of illnesses. However, the influence of cuproptosis-related genes in MDD has not been comprehensively assessed in prior study.

Aim

This investigation intends to shed light on the predictive value of cuproptosis-related genes for MDD and the immunological microenvironment.

Methods

GSE38206, GSE76826, GSE9653 databases were used to analyze cuproptosis regulators and immune characteristics. To find the genes that were differently expressed, weighted gene co-expression network analysis was employed. We calculated the effectiveness of the random forest model, generalized lin

SUBMITTER: Lei D 

PROVIDER: S-EPMC10415818 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature