Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice.

ABSTRACT:

Introduction

Chronic neuroinflammation can exist for months to years following traumatic brain injury (TBI), although the underlying mechanisms remain poorly understood.

Methods

In the current study, we used a controlled cortical impact mouse model of TBI to examine whether proinflammatory senescent cells are present in the brain long-term (months) after TBI and whether ablation of these cells via administration of senolytic drugs can improve long-term functional outcome after TBI. The results revealed that astrocytes and microglia in the cerebral cortex, hippocampus, corpus callosum and lateral posterior thalamus colocalized the senescent cell markers, p16^Ink4a or p21^Cip1/Waf1 at 5 weeks post injury (5wpi) and 4 months post injury (4mpi) in a controlle

SUBMITTER: Wang J 

PROVIDER: S-EPMC10416099 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature