Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives.

ABSTRACT: MicroRNAs (miRNAs) are short (18-25 nt), non-coding, widely conserved RNA molecules responsible for regulating gene expression via sequence-specific post-transcriptional mechanisms. Since the human miRNA transcriptome regulates the expression of a number of tumor suppressors and oncogenes, its dysregulation is associated with the clinical onset of different types of cancer. Despite the fact that numerous therapeutic approaches have been designed in recent years to treat cancer, the complexity of the disease manifested by each patient has prevented the development of a highly effective disease management strategy. However, over the past decade, artificial miRNAs (i.e., anti-miRNAs and miRNA mimics) have shown promising results against various cancer types; nevertheless, their targeted deliv

SUBMITTER: Bravo-Vazquez LA 

PROVIDER: S-EPMC10416113 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature