Recent advances in the treatment of complex congenital diaphragmatic hernia-a narrative review.

ABSTRACT:

Background and objective

Congenital diaphragmatic hernia (CDH) is an anomaly of the cardiopulmonary system maturation process that results from both a global embryopathy and concomitant mechanical compression of the cardiopulmonary system from the abdominal contents during fetal maturation. This results in pulmonary hypertension, pulmonary hypoplasia, and cardiac dysfunction, requiring intense critical care management. The patients with highest risk CDH are the most challenging, resource-intensive, and bear most of the mortality. Advances at the basic, translational, and clinical research levels are leading to novel therapies and management strategies for complex, high-risk CDH. Our objective is to review novel approaches in thinking and management for the most complex and high-ris

SUBMITTER: Holden KI 

PROVIDER: S-EPMC10416132 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature