Esketamine versus placebo on time to remission in major depressive disorder with acute suicidality.

ABSTRACT:

Background

Esketamine (ESK) nasal spray, taken with oral antidepressant therapy, is approved for the treatment of depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior. In pooled analyses of two pivotal phase 3 studies, ASPIRE I and II, remission rates were consistently higher among patients with MDD with active suicidality who were treated with ESK + standard of care (SOC) versus placebo (PBO) + SOC at all time points in the double-blind and most time points in the follow-up phases. The current analysis of the ASPIRE data sets assessed the effect of ESK + SOC versus PBO + SOC on additional remission-related endpoints: time to achieving remission and consistent remission, proportion of patients in remission and consistent remiss

SUBMITTER: Fu DJ 

PROVIDER: S-EPMC10416356 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature