Diminished activation of excitatory neurons in the prelimbic cortex leads to impaired working memory capacity in mice.

ABSTRACT:

Background

Working memory capacity impairment is an early sign of Alzheimer's disease, but the underlying mechanisms remain unclear. Clarifying how working memory capacity is affected will help us better understand the pathological mechanism of Alzheimer's disease. We used the olfactory working memory capacity paradigm to evaluate memory capacity in 3-month-old 5XFAD (an animal model of Alzheimer's disease) mice. Immunofluorescence staining of the prefrontal cortex was performed to detect the number of FOS-positive neurons, calmodulin-dependent protein kinase II-positive neurons, and glutamate decarboxylase-positive neurons in the prelimbic cortex and infralimbic cortex. A chemogenetic method was then used to modulate the inhibition and activation of excitatory neurons in the preli

SUBMITTER: Jiang LX 

PROVIDER: S-EPMC10416384 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature