Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways.

ABSTRACT: According to the World Health Organization (WHO), air pollution is one of the most serious threats for our planet. Despite a growing public awareness of the harmful effects of air pollution on human health, the specific influence of particulate matter (PM) on human immune cells remains poorly understood. In this study, we investigated the effect of PM on peripheral blood monocytes in vitro. Monocytes from healthy donors (HD) were exposed to two types of PM: NIST (SRM 1648a, standard urban particulate matter from the US National Institute for Standards and Technology) and LAP (SRM 1648a with the organic fraction removed). The exposure to PM-induced mitochondrial ROS production followed by the decrease of mitochondrial membrane potential and activation of apoptotic protease activating factor

SUBMITTER: Galuszka-Bulaga A 

PROVIDER: S-EPMC10416410 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature