Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer.

ABSTRACT:

Background

The most common cause of death for colon cancer patients is liver metastasis.

Methods

All the data enrolled in this study were downloaded from two public databases, The Cancer Genome Atlas Program, the TCGA-COAD project and Gene Expression Omnibus, GSE41258 project. All the analysis was performed in R software.

Results

In our study, we systematically explored the molecules involved in the liver metastasis process of colon cancer. The biological role of these molecules was identified through the GO and KEGG analysis. Moreover, we identified that the molecules SERPINA3, SERPINA1, MMP3, ALDH1A3, PBK and CXCL14 were the independent factors for patients survival. The CXCL14 was selected for further analysis for its most significant P value. Single-cell analysis

SUBMITTER: Zhou L 

PROVIDER: S-EPMC10416425 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature