Relationship between cancer stem cell-related SNPs and survival outcomes in patients with primary lung cancer.

ABSTRACT:

Background

Cancer stem cells may be the source of cancer-causing mutant cells and are closely related to the prognosis of cancer. Our study aimed to investigate the potential association between single-nucleotide polymorphisms (SNPs) of cancer stem cell-related genes and the prognosis of lung cancer patients.

Methods

The SNP loci were genotyped by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS), and the overall survival of subjects was analyzed by log-rank test after stratifying and adjusting their demographic data, clinical data, and genotypes. The correlation between survival time and quality of life of lung cancer under codominant, dominant, recessive, and additive genetic models was analyzed by the Cox regression model. The ass

SUBMITTER: Xu X 

PROVIDER: S-EPMC10416443 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature