Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization.

ABSTRACT:

Background

There are many studies indicating that alterations in the abundance of certain gut microbiota are associated with colorectal cancer (CRC). However, a causal relationship has not been identified due to confounding factors such as lifestyle, environmental, and possible reverse causal associations between the two. Furthermore, certain host gene mutations can also contribute to the development of CRC. However, the association between genes and gut microbes in patients with CRC has not been extensively studied.

Methods

We conducted a two-sample Mendelian randomization (MR) study to reveal the causal relationship between gut microbiota and CRC. We obtained SNPs associated with gut microbiome abundance as instrumental variables (IVs) from a large-scale, multi-ethnic GWAS

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC10416448 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature