Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation.

ABSTRACT:

Background

Cardiomyocyte growth and differentiation rely on precise gene expression regulation, with epigenetic modifications emerging as key players in this intricate process. Among these modifications, N6-methyladenosine (m6A) stands out as one of the most prevalent modifications on mRNA, exerting influence over mRNA metabolism and gene expression. However, the specific function of m6A in cardiomyocyte differentiation remains poorly understood.

Results

We investigated the relationship between m6A modification and cardiomyocyte differentiation by conducting a comprehensive profiling of m6A dynamics during the transition from pluripotent stem cells to cardiomyocytes. Our findings reveal that while the overall m6A modification level remains relatively stable, the m6A levels o

SUBMITTER: Liu XH 

PROVIDER: S-EPMC10416456 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature