Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations.

ABSTRACT:

Background

It is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or with changes in the amino acid contents of proteins. Recently, evidence has accumulated that significant evolutionary transformations could also be associated with the loss/emergence of whole genes. The targeted identification of such genes is a challenging problem for both bioinformatics and evo-devo research.

Results

To solve this problem we propose the WINEGRET method, named after the first letters of the title. Its main idea is to search for genes that satisfy two requirements: first, the desired genes were lost/emerged at the same evolutionary stage at w

SUBMITTER: Lyubetsky VA 

PROVIDER: S-EPMC10416458 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature