Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?

ABSTRACT:

Background

Children with brain tumors are at high risk of neurocognitive decline after radiotherapy (RT). However, there is a lack of studies on how RT doses to organs at risk (OARs) impacts neurocognition. The aim of this study was to examine dose-risk relationships for mean RT dose to different brain structures important for neurocognitive networks. We explored previously established OARs and potentially new OARs.

Methods

A sample of 44 pediatric brain tumor survivors who had received proton and/or photon RT were included. Correlations between mean RT doses to OARs and IQ were analyzed. Previously established OARs were cochleae, optic chiasm, optic nerve, pituitary gland, hypothalamus, hippocampus and pons. Potential new OARs for RT-induced neurocognitive decline were cere

SUBMITTER: Soderstrom H 

PROVIDER: S-EPMC10416465 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature