Network analysis of neuropsychiatric symptoms in Alzheimer's disease.

ABSTRACT:

Background

Neuropsychiatric symptoms due to Alzheimer's disease (AD) and mild cognitive impairment (MCI) can decrease quality of life for patients and increase caregiver burden. Better characterization of neuropsychiatric symptoms and methods of analysis are needed to identify effective treatment targets. The current investigation leveraged the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) to examine the network structure of neuropsychiatric symptoms among symptomatic older adults with cognitive impairment.

Methods

The network relationships of behavioral symptoms were estimated from Neuropsychiatric Inventory Questionnaire (NPI-Q) data acquired from 12,494 older adults with MCI and AD during their initial visit. Network analysis provides insight into

SUBMITTER: Goodwin GJ 

PROVIDER: S-EPMC10416506 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature