A heparin-binding protein of Plasmodium berghei is associated with merozoite invasion of erythrocytes.

ABSTRACT:

Background

Malaria caused by Plasmodium species is a prominent public health concern worldwide, and the infection of a malarial parasite is transmitted to humans through the saliva of female Anopheles mosquitoes. Plasmodium invasion is a rapid and complex process. A critical step in the blood-stage infection of malarial parasites is the adhesion of merozoites to red blood cells (RBCs), which involves interactions between parasite ligands and receptors. The present study aimed to investigate a previously uncharacterized protein, PbMAP1 (encoded by PBANKA_1425900), which facilitates Plasmodium berghei ANKA (PbANKA) merozoite attachment and invasion via the heparan sulfate receptor.

Methods

PbMAP1 protein expression was investigated at the asexual blood stage, and its specific

SUBMITTER: Gao J 

PROVIDER: S-EPMC10416508 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature