Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis.

ABSTRACT:

Background

Emerging evidence suggests that remnant cholesterol (RC) is strongly associated with an increased incidence of cardiometabolic diseases (CMD). However, the causality have not been confirmed. We aimed to evaluate the causal associations of RC with CMD and the relative risk factors using two-sample Mendelian randomization (MR) methods.

Methods

Summary-level statistics of RC, CMD, and cardiometabolic risk factors were obtained from the published data from individuals with a predominantly European ancestry mainly from the UK Biobank and the FinnGen biobank. Univariable and multivariable MR analyses were used to evaluate the causal relationships between RC and CMD. A bidirectional MR analysis was performed to estimate the causality between RC and cardiometabolic risk f

SUBMITTER: Guan B 

PROVIDER: S-EPMC10416527 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature