Combination strategies to overcome drug resistance in FLT⁺ acute myeloid leukaemia.

ABSTRACT:

Background

Acute myeloid leukaemia (AML) remains difficult to treat despite the development of novel formulations and targeted therapies. Activating mutations in the FLT3 gene are common among patients and make the tumour susceptible to FLT3 inhibitors, but resistance to such inhibitors develops quickly.

Methods

We examined combination therapies aimed at FLT3⁺-AML, and studied the development of resistance using a newly developed protocol. Combinations of FLT3, CDK4/6 and PI3K inhibitors were tested for synergism.

Results

We show that AML cells express CDK4 and that the CDK4/6 inhibitors palbociclib and abemaciclib inhibit cellular growth. PI3K inhibitors were also effective in inhibiting the growth of AML cell lines that express FLT3-ITD. Whereas resistanc

SUBMITTER: Yang J 

PROVIDER: S-EPMC10416533 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature