Leishmania infection alters macrophage and dendritic cell migration in a three-dimensional environment.

ABSTRACT: Background: Leishmaniasis results in a wide spectrum of clinical manifestations, ranging from skin lesions at the site of infection to disseminated lesions in internal organs, such as the spleen and liver. While the ability of Leishmania-infected host cells to migrate may be important to lesion distribution and parasite dissemination, the underlying mechanisms and the accompanying role of host cells remain poorly understood. Previously published work has shown that Leishmania infection inhibits macrophage migration in a 2-dimensional (2D) environment by altering actin dynamics and impairing the expression of proteins involved in plasma membrane-extracellular matrix interactions. Although it was shown that L. infantum induces the 2D migration of dendritic cells,

SUBMITTER: Luz Y 

PROVIDER: S-EPMC10416637 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature