Treating Hyperexcitability in Human Cerebral Organoids Resulting from Oxygen-Glucose Deprivation.

ABSTRACT: Human cerebral organoids resemble the 3D complexity of the human brain and have the potential to augment current drug development pipelines for neurological disease. Epilepsy is a complex neurological condition characterized by recurrent seizures. A third of people with epilepsy do not respond to currently available pharmaceutical drugs, and there is not one drug that treats all subtypes; thus, better models of epilepsy are needed for drug development. Cerebral organoids may be used to address this unmet need. In the present work, human cerebral organoids are used along with electrophysiological methods to explore oxygen-glucose deprivation as a hyperexcitability agent. This activity is investigated in its response to current antiseizure drugs. Furthermore, the mechanism of action of the d

SUBMITTER: Santos AC 

PROVIDER: S-EPMC10416870 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature