The Evolving Landscape of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma.

ABSTRACT: The role of cytoreductive nephrectomy in metastatic renal cell carcinoma (RCC) has been studied intensively over the past few decades. Interestingly, the opinion with regard to the importance of this procedure has switched from a recommendation as a standard of care to an almost complete refutation. However, no definitive agreement on cytoreductive nephrectomy, including the pros and cons of the procedure, has been reached, and the topic remains highly controversial. With the advent of immune checkpoint inhibitors, we have experienced a paradigm shift, with immunotherapy playing a crucial role in the treatment algorithm. Nevertheless, obtaining results from prospective clinical trials on the role of cytoreductive nephrectomy requires time, and once some data have been gathered, the standar

SUBMITTER: Studentova H 

PROVIDER: S-EPMC10417043 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature