Mutational pattern off homologous recombination repair (HRR)-related genes in upper tract urothelial carcinoma.

ABSTRACT:

Background

Homologous recombination (HR) repair (HRR) has been indicated to be a biomarker for immunotherapy, chemotherapy, and poly-ADP ribose polymerase inhibitors inhibitors (PARPis). Nonetheless, their molecular correlates in upper tract urothelial carcinoma (UTUC) have not been well studied. This study aimed to explore the molecular mechanism and tumor immune profile of HRR genes and the relevance of their prognostic value in patients with UTUC.

Materials and methods

One hundred and ninety-seven tumors and matched blood samples from Chinese UTUC were subjected to next-generation sequencing. A total of 186 patients from The Cancer Genome Atlas were included. Comprehensive analysis was performed.

Results

In Chinese patients with UTUC, 5.01% harbored germline HRR ge

SUBMITTER: Yang K 

PROVIDER: S-EPMC10417099 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature