The genetic polymorphisms of immune-related genes contribute to the susceptibility and survival of lymphoma.

ABSTRACT:

Background

Though immunological abnormalities have been proven involved in the pathogenesis of lymphoma, the underlying mechanism remains unclear.

Methods

We investigated 25 single nucleotide polymorphisms (SNPs) of 21 immune-related genes and explored their roles in lymphoma. The genotyping assay of the selected SNPs was used by the Massarray platform. Logistic regression and Cox proportional hazards models were used to analyze the associations of SNPs and the susceptibility of lymphoma or clinical characteristics of lymphoma patients. In addition, Least Absolute Shrinkage and Selection Operator regression was used to further analyze the relationships with the survival of lymphoma patients and candidate SNPs, and the significant difference between genotypes was verified by

SUBMITTER: Gu C 

PROVIDER: S-EPMC10417154 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature