Genetic and lifestyle factors for breast cancer risk assessment in Southeast China.

ABSTRACT:

Background

Despite the rising incidence and mortality of breast cancer among women in China, there are currently few predictive models for breast cancer in the Chinese population and with low accuracy. This study aimed to identify major genetic and life-style risk factors in a Chinese population for potential application in risk assessment models.

Methods

A case-control study in southeast China was conducted including 1321 breast cancer patients and 2045 controls during 2013-2016, in which the data were randomly divided into a training set and a test set on a 7:3 scale. The association between genetic and life-style factors and breast cancer was examined using logistic regression models. Using AUC curves, we also compared the performance of the logistic model to machine lear

SUBMITTER: Zou S 

PROVIDER: S-EPMC10417168 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature