Disease-associated gut microbiome and critical metabolomic alterations in patients with colorectal cancer.

ABSTRACT:

Background

Gut microbiota plays a significant role in the colorectal cancer (CRC) process. Ectopic colonization of multiple oral bacteria is reportedly associated with CRC pathogenesis and progression, but the details remain unclear.

Methods

We enrolled a cohort of 50 CRC patients and 52 healthy controls from an East China population. Taxonomic and functional analysis of the fecal microbiota were performed using 16S rDNA (50 + 52 samples) and shotgun metagenomic sequencing (8 + 6 samples), respectively, with particular attention paid to gut-colonized oral bacteria.

Results and conclusions

The results showed more detected bacterial species but lower species evenness within the samples from CRC patients. To determine the specific bacteria enriched in each group, we anal

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10417192 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature