Nicotinamide N-Methyl Transferase as a Predictive Marker of Tubular Fibrosis in CKD.

ABSTRACT:

Purpose

Chronic kidney disease (CKD) progression is complex. There are not standardized methods for predicting the prognosis of CKD. Nicotinamide N-methyltransferase (NNMT) has been shown to be associated with renal fibrosis. This study aimed to validate NNMT as a prognostic biomarker of progressive CKD.

Patients and methods

We explored the relationship between NNMT expression and CKD-related outcome variables using the NephroseqV5 and GEO databases. Additionally, a validation set of 37 CKD patients was enrolled to measure the correlation between NNMT expression levels and CKD outcomes. Furthermore, single-cell RNA sequencing data and the Human Protein Atlas were reanalyzed to investigate the expression specificity of NNMT in the kidney. Finally, to detect the status of NNMT

SUBMITTER: Ye Q 

PROVIDER: S-EPMC10417815 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature