Ontology highlight
ABSTRACT:
SUBMITTER: Miao Z
PROVIDER: S-EPMC10418058 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Miao Zhen Z Wang Jianqiao J Park Kernyu K Kuang Da D Kim Junhyong J
bioRxiv : the preprint server for biology 20240324
Single nucleus ATAC-seq (snATAC-seq) experimental designs have become increasingly complex with multiple factors that might affect chromatin accessibility, including genotype, cell type, tissue of origin, sample location, batch, etc., whose compound effects are difficult to test by existing methods. In addition, current snATAC-seq data present statistical difficulties due to their sparsity and variations in individual sequence capture. To address these problems, we present a zero-adjusted statis ...[more]