Context-invariant beliefs are supported by dynamic reconfiguration of single unit functional connectivity in prefrontal cortex.

ABSTRACT: Natural behaviors occur in closed action-perception loops and are supported by dynamic and flexible beliefs abstracted away from our immediate sensory milieu. How this real-world flexibility is instantiated in neural circuits remains unknown. Here we have macaques navigate in a virtual environment by primarily leveraging sensory (optic flow) signals, or by more heavily relying on acquired internal models. We record single-unit spiking activity simultaneously from the dorsomedial superior temporal area (MSTd), parietal area 7a, and the dorso-lateral prefrontal cortex (dlPFC). Results show that while animals were able to maintain adaptive task-relevant beliefs regardless of sensory context, the fine-grain statistical dependencies between neurons, particularly in 7a and dlPFC, dynamically rem

SUBMITTER: Noel JP 

PROVIDER: S-EPMC10418097 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature