Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model.

ABSTRACT: Migraine headache is hypothesized to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. To better understand migraine pathophysiology and improve clinical translation, we used two-photon calcium imaging via a closed cranial window in awake mice to investigate changes in the responses of meningeal afferent fibers using a preclinical model of migraine involving cortical spreading depolarization (CSD). A single CSD episode caused a seconds-long wave of calcium activation that propagated across afferents and along the length of individual afferents. Surprisingly, unlike previous studies in anesthetized animals with exposed meninges, only a very small afferent population was persistently activated in our awake mouse preparation, questio

SUBMITTER: Blaeser AS 

PROVIDER: S-EPMC10418100 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature