Probing Bioactive Chemical Space to Discover RNA-Targeted Small Molecules.

ABSTRACT: Small molecules have become increasingly recognized as invaluable tools to study RNA structure and function and to develop RNA-targeted therapeutics. To rationally design RNA-targeting ligands, a comprehensive understanding and explicit testing of small molecule properties that govern molecular recognition is crucial. To date, most studies have primarily evaluated properties of small molecules that bind RNA in vitro , with little to no assessment of properties that are distinct to selective and bioactive RNA-targeted ligands. Therefore, we curated an RNA-focused library, termed the D uke R NA- T argeted L ibrary (DRTL), that was biased towards the physicochemical and structural properties of biologically active and non-ribosomal RNA-targeted small molecules. The DRTL represents one

SUBMITTER: Wicks SL 

PROVIDER: S-EPMC10418101 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature