Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is considered an inflammatory and neurodegenerative disease of the central nervous system, typically resulting in significant neurological disability that worsens over time. While considerable progress has been made in defining the immune system's role in MS pathophysiology, the contribution of intrinsic CNS-cell dysfunction remains unclear. Here, we generated the largest reported collection of iPSC lines from people with MS spanning diverse clinical subtypes and differentiated them into glia-enriched cultures. Using single-cell transcriptomic profiling, we observed several distinguishing characteristics of MS cultures pointing to glia-intrinsic disease mechanisms. We found that iPSC-derived cultures from people with primary progressive MS contained fewer oligodendr

SUBMITTER: Clayton BLL 

PROVIDER: S-EPMC10418164 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature