The cell adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth in <i>Drosophila</i> imaginal discs.

ABSTRACT: The interactions that cells in Drosophila imaginal discs have with their neighbors are known to regulate their ability to survive. In a screen of genes encoding cell surface proteins for gene knockdowns that affect the size or shape of mutant clones, we found that clones of cells with reduced levels of echinoid (ed) are fewer, smaller, and can be eliminated during development. In contrast, discs composed mostly of ed mutant tissue are overgrown. We find that ed mutant tissue has lower levels of the anti-apoptotic protein Diap1 and has increased levels of apoptosis which is consistent with the observed underrepresentation of ed mutant clones and the slow growth of ed mutant tissue. The eventual overgrowth of ed mutant tissue results no

SUBMITTER: Spitzer DC 

PROVIDER: S-EPMC10418178 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature