Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility.

ABSTRACT: Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.

SUBMITTER: Dershowitz LB 

PROVIDER: S-EPMC10418201 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature