FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse.

ABSTRACT: Mitochondria are not only essential for energy production in eukaryocytes but also a key regulator of intracellular signaling. Here, we report an unappreciated role of mitochondria in regulating cytosolic protein translation in skeletal muscle cells (myofibers). We show that the expression of mitochondrial protein FAM210A (Family With Sequence Similarity 210 Member A) is positively associated with muscle mass in mice and humans. Muscle-specific Myl1^Cre-driven Fam210a knockout (Fam210a^MKO) in mice reduces mitochondrial density and function, leading to progressive muscle atrophy and premature death. Metabolomic and biochemical analyses reveal that Fam210a^MKO reverses the oxidative TCA cycle towards the reductiv

SUBMITTER: Chen J 

PROVIDER: S-EPMC10418219 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature