Short- and Long-Term Regulation of HuD: A Molecular Switch Mediated by Folic Acid?

ABSTRACT: The RNA-binding protein HuD has been shown to play a crucial role in gene regulation in the nervous system and is involved in various neurological and psychiatric diseases. In this study, through the creation of an interaction network on HuD and its potential targets, we identified a strong association between HuD and several diseases of the nervous system. Specifically, we focused on the relationship between HuD and the brain-derived neurotrophic factor (BDNF), whose protein is implicated in several neuronal diseases and is involved in the regulation of neuronal development, survival, and function. To better investigate this relationship and given that we previously demonstrated that folic acid (FA) is able to directly bind HuD itself, we performed in vitro experiments in neuron-like huma

SUBMITTER: Marchesi N 

PROVIDER: S-EPMC10418318 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature