Hydrazinolysis Products of Selected Sugar Lactones-Crystal Structure and Microbiological Activity.

ABSTRACT: Commercially available lactones, as well as those synthesized by us, turned out to be good substrates for the synthesis of sugar hydrazides. The exception was L-ascorbic acid, whose hydrazinolysis led to the formation of a hydrazinium salt, not the hydrazide as expected. The structure of all compounds was confirmed by NMR and X-ray analyses. The lower durability of hydrazinium L-ascorbate was additionally confirmed by thermogravimetric tests. All products were tested for biological activity against Gram-negative bacteria strains Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 and against Gram-positive Staphylococcus aureus ATCC 25923 and Staphylococcus aureus ATCC 29213. Their antifungal activity against Candida albicans SC5314, Candi

SUBMITTER: Samaszko-Fiertek J 

PROVIDER: S-EPMC10418350 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature