Gating of β-Barrel Protein Pores, Porins, and Channels: An Old Problem with New Facets.

ABSTRACT: β barrels are ubiquitous proteins in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. These transmembrane proteins (TMPs) execute a wide variety of tasks. For example, they can serve as transporters, receptors, membrane-bound enzymes, as well as adhesion, structural, and signaling elements. In addition, multimeric β barrels are common structural scaffolds among many pore-forming toxins. Significant progress has been made in understanding the functional, structural, biochemical, and biophysical features of these robust and versatile proteins. One frequently encountered fundamental trait of all β barrels is their voltage-dependent gating. This process consists of reversible or permanent conformational transitions between a large-conductance, highly permeable ope

SUBMITTER: Mayse LA 

PROVIDER: S-EPMC10418385 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature